Ceramides Cream consists of long-chain fatty acids that interact with other important molecules in order to promote cellular function. Ceramides help to create a barrier to prevent permeability. This locks in your skin moisture, helping to prevent dryness and irritation. It can also protect your epidermis against damage to the environment. Ceramides are important to maintain the skin barrier and moisture retention. Skin can become swollen, itchy or irritated without ceramides.